Available Strain Details

Strain Information
Common Strain Name: Sprr2f-Cre Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(Sprr2f-cre)1Dcas/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3

Strain Description: Endometrial CRE deletion line. CRE mediated recombination in endometrial epithelium by 3 weeks of age. CRE also expressed in anatomically related mulerian epithelia (oviduct, cervix). Ectopic expression in cerebellum, kidney.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Cre recombinase
Transgene Symbol: Cre
Promotor Name: small proline-rich protein 2F
Promotor Symbol: Sprr2f
Current Genetic Background: FVB
Approx. Generation: 14
Organ Site: Uterus
Additional Information
Cryopreservation Mating Scheme: The cryopreservation scheme is FVB females x hemizygous males.
Genotyping Information: Protocol 1: Allele: Tg(Sprr2f-cre)1Dcas
Donating Investigator: Dr. Diego Castrillon

Key Reference: Contreras CM, Akbay EA, Gallardo TD, Haynie JM, Sharma S, Tagao O, Bardeesy N, Takahashi M, Settleman J, Wong KK, Castrillon DH. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010 Mar-Apr;3(3-4):181-93. Epub 2010 Feb 8. PMID: 20142330 [Pubmed Abstract]

Sponsor: The American Cancer Society, National Cancer Institute, Sidney Kimmel Translational Science Awards, Cancer Prevention and Research Institute of Texas, Simmons Comprehensive Cancer Center