Available Strain Details

Strain Information
Common Strain Name: BLBP-cre Pricing and Ordering Information
Strain Nomenclature: B6;CB-Tg(Fabp7-creLacZ)3Gtm/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): C1

Strain Description: The BLBP-Cre mice were developed to allow for Cre-mediated inactivation (or overexpression) in neural stem cells. The transgene used to develop these mice included a 1.6kb fragment of the mouse brain lipid binding protein (BLBP or B-FABP) promoter, a nuclear-targeted Cre recombinase cDNA, and a LacZ reporter expressed from an internal ribosomal entry site (IRES), so that both Cre and LacZ are co-expressed. Cre recombinase transgene expression is first detected in the subventricular zone and hippocampus at embryonic day 9.5 and coincides with endogenous BLBP expression.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Cre recombinase, LacZ
Transgene Symbol: CreLacZ
Promotor Name: Fabp7, mouse
Promotor Symbol: Fabp7
Current Genetic Background: B6;CB
Approx. Generation: 4
Organ Site: Brain
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is C57BL/6 females x hemizygous males. SPERM: Sperm was obtained from hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype C57BL/6 (male or female). Average litter size is 10.
Genotyping Information: Protocol 1: Allele: Tg(Fabp7-creLacZ)3Gtm
Donating Investigator: Dr. David H. Gutmann

Key Reference: Cell Stem Cell. 2007 Oct 11;1(4):443-57. doi: 10.1016/j.stem.2007.07.008. Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Hegedus B1, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH. PMID 18371380 [Pubmed Abstract]

Sponsor: NCI MMHCC U01 CA84313-06