Available Strain Details

Strain Information
Common Strain Name: Nf1 flox Pricing and Ordering Information
Strain Nomenclature: B6;129-Nf1tm1Par/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: These mice carry a floxed allele of Nf1 with LoxP sites in introns 30 and 32. The animals are phenotypically normal; homozygous mice are viable. This is a useful strain for the study of neurofibromatosis and other cancers associated with loss of Nf1 function.
Mutation Information
Mutation Type: Targeted
Gene Name: Neurofibromatosis 1
Gene Symbol: Nf1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation: 13
Organ Site: Brain, Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote male x wildtype C57BL/6 female.
Genotyping Information: Protocol 1: Allele: Nf1<tm1Par>
Donating Investigator: Dr. Luis Parada

Key Reference: Zhu Y; Romero MI; Ghosh P; Ye Z; Charnay P; Rushing EJ; Marth JD; Parada LF. Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev 15, 859-876, 2001. PMID: 11297510. [Pubmed Abstract]