Available Strain Details

Strain Information
Common Strain Name: p53 R172H Pricing and Ordering Information
Strain Nomenclature: 129S4-Trp53tm2.1Tyj/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3

Strain Description: These mice express point-mutant p53 under control of the endogenous Trp53 promoter. Heterozygous mice have an increased tumor burden relative to Trp53+/- mice but similar survival curves. The animals show a broad tumor spectrum with an increased frequency of carcinomas, osteosarcomas, hemangiosarcomas, and lymphoblastic lymphomas. Osteosarcomas are more frequently metastatic. An improved model for Li-Fraumeni Syndrome.
Mutation Information
Mutation Type: Targeted
Gene Name: Transformation related protein 53
Gene Symbol: Trp53
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: 129S4
Approx. Generation: 9
Organ Site: multiple
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is 129S4 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as heterozgyotes. Homozygotes are fertile and viable but have decreased fertility and short lifespan. Easiest to maintain as heterozygotes.
Genotyping Information: Protocol 1: Allele: Trp53<tm2.1Tyj>
Donating Investigator: Dr. Tyler Jacks

Key Reference: Olive KP, Tuveson DA, Ruhe ZC, Yin B, Willis NA, Bronson RT, Crowley D, Jacks T. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004 Dec 17;119(6):847-60. PMID: 15607980 [Pubmed Abstract]