Available Strain Details

Strain Information
Common Strain Name: Hi-Myc Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(ARR2/Pbsn-MYC)7Key/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): C1

Strain Description: These mice express human c-Myc in the mouse prostate. They develop PIN lesions as early as 2 weeks which progress to cancer by 6 months. They serve as a good tool to study the progression of prostate cancer in a mouse model.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: human
Transgene Symbol: c-Myc
Promotor Name: AAR2-probasin, rat, composite
Promotor Symbol: AAR2-Pbsn
Current Genetic Background: FVB
Approx. Generation: 32
Organ Site: Prostate
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is FVB females x hemizygous males. SPERM: Sperm was obtained from hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype FVB (male or female).
Genotyping Information: Protocol 1: Allele: Tg(ARR2/Pbsn-MYC)7Key
Donating Investigator: Dr. Charles Sawyers

Key Reference: Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. Myc-driven murine prostate cancer shares molecular features with human prostate tumors (2003), Cancer Cell 4, 223-238. PMID: 14522256 [Pubmed Abstract]