Available Strain Details

Strain Information
Common Strain Name: ATR flox/+ (129SvEv) Pricing and Ordering Information
Strain Nomenclature: 129S.129S2-Atrtm2Bal/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3

Strain Description: ATRflox/+ mice may be used to generate ATR conditional knockout mice, useful due to the embryonic lethality of ATR-/- homozygotes.
Mutation Information
Mutation Type:
Gene Name: Ataxia Telangiectasia And Rad3-Related Protein
Gene Symbol: ATR
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: 129S.129S2
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The embryo cryopreservation mating scheme is homozygous males x wildtype females; SPERM: Sperm was obtained from homozyous males.
Genotyping Information: Protocol 1: Allele: ATR<tm2Bal>/Nci
Donating Investigator: Dr. Eric Brown

Key Reference: Brown EJ, Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 2003 Mar 1;17(5):615-28. PMID: 12629044 [Pubmed Abstract]

Related Reference: Gasser S1, Orsulic S, Brown EJ, Raulet DH.The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.Nature. 2005 Aug 25;436(7054):1186-90. Epub 2005 Jul 3. PMID: 15995699 [Pubmed Abstract]

Ruzankina Y1, Pinzon-Guzman C, Asare A, Ong T, Pontano L, Cotsarelis G, Zediak VP, Velez M, Bhandoola A, Brown EJ. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.Cell Stem Cell. 2007 Jun 7;1(1):113-26. doi: 10.1016/j.stem.2007.03.002. PMID: 18371340 [Pubmed Abstract]

Onksen JL1, Brown EJ, Blendy JA.Selective deletion of a cell cycle checkpoint kinase (ATR) reduces neurogenesis and alters responses in rodent models of behavioral affect.Neuropsychopharmacology. 2011 Apr;36(5):960-9. doi: 10.1038/npp.2010.234. Epub 2011 Jan 19. PMID: 21248719 [Pubmed Abstract]