Available Strain Details

Strain Information
Common Strain Name: Mdm-2flox Pricing and Ordering Information
Strain Nomenclature: 129(Cg)-Mdm2tm1.2Mep/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: This strain carries a conditional allele of mdm2 that functions as a wild type allele prior to excision by the Cre recombinase. Cre-mediated deletion of exons 7-9 in vivo has been shown. This strain is useful for studying functions of Mdm2, an essential inhibitor of p53.
Mutation Information
Mutation Type: Targeted
Gene Name: Murine double minute 2
Gene Symbol: Mdm2
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: 129.Cg
Approx. Generation: homo
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is 129S1/SvImJ/Cr females x homozgyous males or 129S1/SvImJ/Cr females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Mdm2<tm1.2Mep>
Protocol 2: Allele: Mdm2<tm1.2Mep>
Donating Investigator: Dr. Mary Ellen Perry

Key Reference: Mendrysa SM, McElwee MK, Michalowski J, O'Leary KA, Young KM, and Perry ME. 2003 mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation. Molecular and Cellular Biology 23:462-472. PMID: 12509446 [Pubmed Abstract]