Available Strain Details

Strain Information
Common Strain Name: Ntv-a Pricing and Ordering Information
Strain Nomenclature: STOCK Tg(NES-tv-a)J12Ech/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B1

Strain Description: Transgene expressed in CNS progenitors. No visible phenotype
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Subgroup A avaian leucosis viral receptor
Transgene Symbol: tv-a
Promotor Name: Nestin
Promotor Symbol: NES
Current Genetic Background: STOCK
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: Multiple freezes were done for this strain. EMBRYOS: The cryopreservation mating scheme is homozygous males x FVB/NCr females or heterozygous males x FVB/NCr females. SPERM: Sperm was obtained from heterozgyous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Tg(NES-tv-a)J12Ech
Donating Investigator: Dr. Eric Holland

Key Reference: Holland, E.C., Hively, W.P., DePhino, R.A., and Varmus, H.E. 1998 A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell cycle arrest pathways to induce glioma-like lesions in mice. Genes and Development 12: 3675-3685 PMID: 9851974 [Pubmed Abstract]

Related Reference: Holland, E.C. and Varmus, H.E. 1998 Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. PNAS 95: 1218-1223. PMID: 9448312 [Pubmed Abstract]