Available Strain Details

Strain Information
Common Strain Name: ED-L2/Cre Pricing and Ordering Information
Strain Nomenclature: B6.Cg-Tg(ED-L2-cre)267Jkat/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B2

Strain Description: Cre expression in epithelia of tongue, esophagus, forestomach, with some expresion in ventral neck skin but otherwise no expression in skin. Thus, these mice may be especially useful when gene deletion in skin is lethal.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Cre recombinase
Transgene Symbol: Cre
Promotor Name: ED-L2, origin Epstein Barr Virus (EBV)
Promotor Symbol: ED-L2
Current Genetic Background: B6.Cg
Approx. Generation: 7
Organ Site: Tongue, esophagus stomach
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype C57BL/6 (male or female). Average litter size is 8.
Genotyping Information: Protocol 1: Allele: Tg(ED-L2-cre)267Jkat
Donating Investigator: Dr. Jonathan Katz

Key Reference: Tetreault MP, Yang Y, Travis J, Yu QC, Klein-Szanto A, Tobias JW, Katz JP. Esophageal Squamous Cell Dysplasia and Delayed Differentiation With Deletion of KrĀ¦ppel-Like Factor 4 in Murine Esophagus. Gastroenterology. 2010 Mar 27. [Epub ahead of print]. PMID: 20347813 [Pubmed Abstract]

Related Reference: Nakagawa H, Wang TC, Zukerberg L, Odze R, Togawa K, May GH, Wilson J, Rustgi AK.The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach. Oncogene. 1997 Mar 13;14(10):1185-90. PMID: 9121767 [Pubmed Abstract]

Sponsor: NIH NIDDK R01 DK069984 NIH NIDDK P30 DK050306 NIH NCI P01 CA098101