Available Strain Details

Strain Information
Common Strain Name: LPV-TAg, T121, LST1137, dl1137 Pricing and Ordering Information
Strain Nomenclature: B6;D2-Tg(LPV-TAg121)2Tvd/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: This strain carries only the first 121 amino acids of SV40 Large T antigen, thus the common name of T121. T121 induces abnormal proliferation and apoptosis when expressed in the brain choroid plexus epithelium of transgenic mice, causing slow-growing tumors. From 80 to 90 percent of the apoptosis is dependent of p53. Mice develop a hunched and scruffy appearance with malformed skull before death occurs.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: SV40 Large T antigen
Transgene Symbol: TAg
Promotor Name: lymphotropic papovavirus
Promotor Symbol: LPV
Current Genetic Background: B6;D2
Approx. Generation:
Organ Site: Brain
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is B6D2F1 females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x B6D2F1 (male or female).
Genotyping Information: Protocol 1: Allele: Tg(LPV-TAg121)2Tvd
Donating Investigator: Dr. Terry Van Dyke

Key Reference: Saenz-Robles MT, Symonds H, Chen J, Van Dyke T. 1994. Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen. Mol Cell Biol. 14, 2686-2698. PMID: 8139568 [Pubmed Abstract]

Related Reference: Pipas et al., Mol Cell Biol 3, 203-213, 1983 PMID: 6300656 [Pubmed Abstract]