Available Strain Details

Strain Information
Common Strain Name: Nkx3.1 null (FVB) Pricing and Ordering Information
Strain Nomenclature: FVB.129-Nkx3-1tm1Mms /Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B2

Strain Description: This strain carries a targeted null mutation in the Nkx3-1 (Nkx3.1) gene, which appears to function as a tumor suppressor gene in the prostate. Homozygous males display histological defects resembling prostatic intraepithelial neoplasia (PIN) in humans. These mice appear to provide an accurate model for the early stages of prostate carcinogenesis. PIN-like lesions are less frequent on a 129/SvImJ background than on C57BL/6J or FVB/N. Heterozygous mice display a similar, less severe, phenotype, indicating haploinsufficiency. There is no reported female phenotype.
Mutation Information
Mutation Type: Targeted
Gene Name: NK-3 transcription factor, locus 1 (Drosophilia)
Gene Symbol: Nkx3-1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: FVB.129
Approx. Generation:
Organ Site: Prostate
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB/N Females x homozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes. Males develop prostatic abnormalities. Productivity should be normal for a 6-month rotation.
Genotyping Information: Protocol 1: Allele: Nkx3.1<tm1Mms>
Donating Investigator: Dr. Cory Abate-Shen

Key Reference: Kim MJ, Bhatia-Gaur R, Banach-Petrosky WA, Desai N, Wang Y, Hayward SW, Cunha GR, Cardiff RD, Shen MM, Abate-Shen C. 2002 Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis. Cancer Res. 62:2999-3004 PMID: 12036903 [Pubmed Abstract]