Available Strain Details

Strain Information
Common Strain Name: p19(Arf) null (B6;129) Pricing and Ordering Information
Strain Nomenclature: B6;129-Cdkn2atm1Cjs/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3

Strain Description: Exon 1b of the mouse Cdkn2a gene was ablated. These mice express p16(Ink4a) but not p19(Arf). A variety of tumors (fibrosarcoma, thymoma, lymphoma) begin to develop at 2 months of age.
Mutation Information
Mutation Type: Targeted
Gene Name: Cyclin-dependent kinase inhibitor 2A
Gene Symbol: Cdkn2a
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation: 12
Organ Site: All
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x homozygous males or C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes. Mice develop tumors at 2 months of age.
Genotyping Information: Protocol 1: Allele: Cdkn2a<tm1Cjs>
Donating Investigator: Dr. Charles Sherr

Key Reference: Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, Ashmun RA, Grosveld G, Sherr CJ. 1997 Tumor suppression at the mouse INK4a locus mediated by alternative reading frame product p19(Arf). Cell 91:649-59. PMID: 9393858 [Pubmed Abstract]