Available Strain Details

Strain Information
Common Strain Name: Nf1 null (B6) Pricing and Ordering Information
Strain Nomenclature: B6.129S6-Nf1tm1Fcr/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: Nf1-/- embryos die between E11-E13.5 with heart defects and hyperplasia of the superior ganglia. Heterozygotes have an increased predisposition to pheochromocytoma and myeloid leukemia between 18 and 28 months of age. Heterozygotes also exhibit features of the learning deficits associated with NF1 patients, which has been shown to be associated with overactive Ras function (Costa RM et.al. 2001. Nature).
Mutation Information
Mutation Type: Targeted
Gene Name: Neurofibromatosis 1
Gene Symbol: Nf1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129S6
Approx. Generation: 11
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Nf1<tm1Fcr>
Donating Investigator: Dr. Luis Parada

Key Reference: Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG. 1994. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev 8:1019-1029. PMID: 7926784 [Pubmed Abstract]