Available Strain Details

Strain Information
Common Strain Name: Tg p53 R172H Pricing and Ordering Information
Strain Nomenclature: FVB/N-Tg(Trp53R172H)8512Jmr/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B2

Strain Description: Transgene expression alone exerts no apparent effect on normal mammary gland development up to a year of age in the FVB background. Mice treated with the chemical carcinogen, dimethylbenz(a)anthracine (DMBA), or crossed with mice overexpressing erb-B2 or desIGF-1 develop tumors with significantly shorter latencies than controls. These tumors are characterized by large pleiomorphic nuclei and genomic instability. Spontaneous tumors are rarely observed in multiply bred animals during the first year of life.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Transformation related protein 53
Transgene Symbol: Trp53
Promotor Name: Whey acidic protein (rat)
Promotor Symbol: WAP
Current Genetic Background: FVB/N
Approx. Generation: 10
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB/N females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype FVB/N (male or female).
Genotyping Information: Protocol 1: Allele: Tg(Trp53R172H)8512Jmr
Donating Investigator: Dr. Jeffrey Rosen

Key Reference: Li B, Murphy KL, Laucirica R, Kittrell F, Medina D, Rosen JM. 1998. A transgenic mouse model for mammary carcinogenesis. Oncogene 16 :997-1007. PMID: 9519874 [Pubmed Abstract]

Related Reference: Murphy KL, Dennis AP, Rosen JM. 2000. A gain of function p53 mutant promotes both genomic instability and cell survival in a novel -53-null mammary epithelial cell model. FASEB Journal 14:2291-302. PMID: 11053251 [Pubmed Abstract]