Available Strain Details

Strain Information
Common Strain Name: p16(Ink4a) null Pricing and Ordering Information
Strain Nomenclature: FVB.129-Cdkn2atm2.1Rdp/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): C3

Strain Description: The loss of the p16(Ink4a) tumor suppressor gene (sometimes accompanied by the simultaneous loss of p19(Arf)) plays a role in both human and murine tumor development. This strain carries a null allele of the p16(Ink4a) gene while retaining normal p19(Arf) function. Mice carrying this allele exhibit thymic hyperplasia, enhanced T-cell proliferative responses and increased spontaneous and carcinogen-induced (DMBA and urethane) tumors. Spontaneous tumors are mostly sarcomas and lymphomas, the median tumor free survival is ~75 weeks.
Mutation Information
Mutation Type: Targeted
Gene Name: Cyclin-dependent kinase inhibitor 2A
Gene Symbol: Cdkn2a
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: FVB.129
Approx. Generation: Homo
Organ Site: Hematopoietic, Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB/N Females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Cdkn2a<tm2.1Rdp>
Donating Investigator: Dr. Ron DePinho

Key Reference: Sharpless ME, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. 2001 Loss of p16(Ink4a) with retention of p19(Arf) predisposes mice to tumorigenesis. Nature, 413:86-91. PMID: 11544531 [Pubmed Abstract]