Available Strain Details

Strain Information
Common Strain Name: Dicer-conditional Pricing and Ordering Information
Strain Nomenclature: B6;129S7-Dicer1tm1Snj/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3,C1

Strain Description: This model undergoes Cre-mediated Dicer ablation, which induces rapid senescence that can be rescued by loss of Ink4a and/or p53. Co-deletion of p53 and Dicer leads to reduced miRNA processing, DNA damage accumulation, and the formation of SCC and BSC in the skin.
Mutation Information
Mutation Type: Targeted
Gene Name: Dicer
Gene Symbol: Dicer
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129S7
Approx. Generation:
Organ Site: all
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6NCr females x heterozygote males
Genotyping Information: Protocol 1: Allele: Dicer1<tm1Snj>/Nci
Donating Investigator: Dr. Stephen Jones

Key Reference: Mudhasani, R. et al. (2008) J. Cell Biology 181:1055-1063.PMID 18591425; MGI 5898382 [Pubmed Abstract]

Related Reference: Lyle, S. et al (2014) PLoS-One. 9(6):e100920. doi: 10.1371. PMID 24979267 [Pubmed Abstract]

Sponsor: NIH CA77735, NIH DK73324