Available Strain Details

Strain Information
Common Strain Name: s100B-v-erbB (Ink4a-Arf +/-) Pricing and Ordering Information
Strain Nomenclature: B6.Cg-Tg(S100b-v-erbB)4496Waw Cdkn2atm1Rdp/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B2

Strain Description: On an Ink4a/Arf null background these mice are predisposed to high-grade oligodendroglioma. On an Ink4a/Arf wt background they are predisposed to a low-grade oligodendroglioma.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: erythroblastic leukemia viral oncogene homolog
Transgene Symbol: v-erbB
Promotor Name: s100B
Promotor Symbol: s100B
Current Genetic Background: B6.Cg
Approx. Generation: 15
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is Cdkn2a homozygous females x hemizygous transgenic males. When maintained as a live colony, breeder pairs were distributed as a heterozygous (male or female) x wildtype littermate pairs.
Genotyping Information: Protocol 1: Allele: Cdkn2a<tm1Rdp>
Protocol 1: Allele: Tg(s100B-v-erbB)4496Waw
Donating Investigator: Dr. William Weiss

Key Reference: Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 2003 Apr 1;63(7):1589-95. PMID: 12670909 [Pubmed Abstract]