Available Strain Details

Strain Information
Common Strain Name: TH-MYCN Pricing and Ordering Information
Strain Nomenclature: 129X1/SvJ-Tg(TH-MYCN)41Waw/Nci
Animal State: Frozen Sperm
Release Category (Required for MTA form): B2

Strain Description: The rat TH promoter directs expression of the human MYCN transgene to migrating cells of the neural crest during early development. Expression was found in the adrenal gland with marginal expression in brain, heart, testes and spleen. Mice carrying this transgene are predisposed to neuroblastoma and show many of the features of the human childhood disease. Genomic analysis of tumors have shown allelic imbalance in chromosomal regions orthologous to those found in human neuroblastoma.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Neuroblastoma myc-related oncogene 1 (human)
Transgene Symbol: MYCN
Promotor Name: Tyrosine hydroxylase (rat)
Promotor Symbol: TH
Current Genetic Background: 129X1/SvJ
Approx. Generation: 20
Organ Site: CNS
Additional Information
Cryopreservation Mating Scheme: NOTE: THE NCI MOUSE REPOSITORY DISTRIBUTES ONLY CRYOPRESERVED SPERM FOR THIS STRAIN. THE SPERM WAS OBTAINED FROM HEMIZYGOUS MALES. When maintained as a live colony, breeder pairs were distributed as a hemizygote male and a wildtype 129SvJ female.
Genotyping Information: Protocol 1: Allele: Tg(TH-MYCN)41Waw
Donating Investigator: Dr. William Weiss

Key Reference: Weiss WA, Aldape K, Mohapatra G, Feuerstein BG, Bishop JM. 1997 Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J. 16:2985-95. PMID: 9214616 [Pubmed Abstract]

Related Reference: Weiss WA, Godfrey T, Francisco C, Bishop JM. 2000 Genome-wide Screen for Allelic Imbalance in a Mouse Model for Neuroblastoma. Cancer Res. 60: 2483-2487. PMID: 10811128 [Pubmed Abstract]