Available Strain Details

Strain Information
Common Strain Name: Brca1 Exon 11 del Pricing and Ordering Information
Strain Nomenclature: STOCK Brca1tm2.1Cxd/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): C1

Strain Description: This strain carries a hypomorphic mutation of Brca1. Specifically, exon 11, which encodes 60% of the protein, has been deleted from the germline using a Cre-lox strategy. Homozygotes die at E12.5-18.5, however, can be rescued by the haploid loss of p53.
Mutation Information
Mutation Type: Targeted
Gene Name: Breast cancer 1
Gene Symbol: Brca1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation: F6
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is wildtype STOCK females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) and wildtype sibling.
Genotyping Information: Protocol 1: Allele: Brca1<tm2.1Cxd>
Donating Investigator: Dr. CX Deng

Key Reference: Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28, 266-271, 2001. PMID:11431698 [Pubmed Abstract]