Available Strain Details

Strain Information
Common Strain Name: Brca1 floxed (STOCK) Pricing and Ordering Information
Strain Nomenclature: STOCK Brca1tm2Cxd/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): C1

Strain Description: This strain carries a conditional mutation of Brca1 on a mixed genetic background. Specifically, exon 11 is flanked with loxP sites. Mating this strain with any Cre transgenic strain will result in the inactivation of Brca1 wherever Cre is expressed.
Mutation Information
Mutation Type: Targeted
Gene Name: Breast cancer 1
Gene Symbol: Brca1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation: Homo
Organ Site: Breast
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is homozygous x homozygous. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Brca1<tm2Cxd>
Donating Investigator: Dr. CX Deng

Key Reference: Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX. 1999. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet. 22:37-43. PMID: 10319859 [Pubmed Abstract]