Available Strain Details

Strain Information
Common Strain Name: Rb floxed Pricing and Ordering Information
Strain Nomenclature: FVB;129-Rb1tm2Brn/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): C2

Strain Description: This strain carries a conditional mutation in the endogenous Rb1 gene. LoxP sites were inserted into introns surrounding exon 19 in the Rb1 locus. Removal of the region flanked by the LoxP sites results in mice with the same tumor spectrum as mice with a conventional Rb1-null mutation.
Mutation Information
Mutation Type: Targeted
Gene Name: Retinoblastoma 1
Gene Symbol: Rb1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: FVB;129
Approx. Generation: Homo
Organ Site: All
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB Females x homozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Rb1<tm2Brn>
Donating Investigator: Dr. Anton Berns

Key Reference: Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev.14:994-1004. PMID: 10783170 [Pubmed Abstract]