Available Strain Details

Strain Information
Common Strain Name: Trp53-S18A Pricing and Ordering Information
Strain Nomenclature: B6.129S-Trp53tm1Snj/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3,C1

Strain Description: These mice bear a point mutation in a key ATM phosphorylation site in p53 (residue 18). Damage-induced p53 growth arrest is mostly unaffected, whereas apoptosis is altered after DNA damage. The mice are tumor prone (weakly), and are useful in studying the specific effects of p53?mediated apoptosis on biological functions.
Mutation Information
Mutation Type: Targeted
Gene Name: tumor suppresor p53
Gene Symbol: Tp53
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129S
Approx. Generation:
Organ Site:
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is wildtype females x heterozygous males. SPERM: Sperm was obtained from heterozygous males.
Genotyping Information: Protocol 1: Allele: Tp53<tm1Snj>/Nci
Donating Investigator: Dr. Stephen Jones

Key Reference: Sluss, H. et al Mol. Cell. Biol. 24:976-984. PMID 14729946, MGI: 3028920 [Pubmed Abstract]

Related Reference: Sluss, H.K. et al. Mol. Cancer Res. 8:216-222, PMID 20145032 [Pubmed Abstract]

Sponsor: NIH CA77735