Available Strain Details

Strain Information
Common Strain Name: p16INKa4a L Pricing and Ordering Information
Strain Nomenclature: B6.129(Cg)-Cdkn2atm2.1Nesh/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3

Strain Description: Conditional knockout for p16INK4a gene when deleted somatically can cause cancer in selective compartments
Mutation Information
Mutation Type: Targeted
Gene Name: Cyclin-dependent kinase inhibitor 2A
Gene Symbol: Cdkn2a
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129(Cg)
Approx. Generation: Homo
Organ Site:
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is homozygous x homozygous. When maintained as a live colony, breeder pairs were distributed as homozygotes. Average litter size is 8-12.
Genotyping Information: Protocol 1: Allele: B6.129(Cg)-Cdkn2a<tm2.1Nesh>/N
Donating Investigator: Dr. Norman Sharpless

Key Reference: Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NEOncogene. 2010 Oct 28;29(43):5809-17. doi: 10.1038/onc.2010.314. Epub 2010 Aug 9. Somatic p16(INK4a) loss accelerates melanomagenesis. PMID: 20697345 [Pubmed Abstract]

Sponsor: NIH 5-R01-AG24379-09 NIH 1-R01-CA163896-01 NCI 1-U01-CA141576-04