Available Strain Details

Strain Information
Common Strain Name: Tyr-rtTA Pricing and Ordering Information
Strain Nomenclature: FVB-Tg(Tyr-rtTA)37Lc/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: This strain carries the tetracycline reverse transcriptional activator (rtTA) under the control of the tyrosinase promoter/enhancer (Tyr). The rtTA binds to tetracycline operator elements (TetO) in the presence of doxycycline, causing transcriptional activation of genes downstream of TetO. In normal use this strain would be mated with a transgenic strain carrying a transgene under the control of TetO.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: reverse tetracycline-controlled transactivator
Transgene Symbol: rtTA
Promotor Name: tyrosinase promoter/enhancer
Promotor Symbol: Tyr
Current Genetic Background: FVB
Approx. Generation: 18
Organ Site: Skin
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is FVB females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype FVB (male or female).
Genotyping Information: Protocol 1: Allele: Tg(Tyr-rtTA)37Lc
Donating Investigator: Dr. Lynda Chin

Key Reference: Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW 2nd, Cordon-Cardo C, Yancopoulos GD, DePinho RA. 1999. Essential role for oncogenic Ras in tumour maintenance. Nature 400:468-72. PMID: 10440378 [Pubmed Abstract]