Available Strain Details

Strain Information
Common Strain Name: Nkx3.1 null (B6;129) Pricing and Ordering Information
Strain Nomenclature: B6;129-Nkx3-1tm1Mms/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B2

Strain Description: This strain carries a targeted null mutation in the Nkx3-1 (Nkx3.1) gene, which appears to function as a tumor suppressor gene in the prostate. Homozygous males display prostatic epithelial hyperplasia and dysplasia that increases with age. Heterozygous mice display a similar, less severe, phenotype, indicating haploinsufficiency. There are also defects in prostate ductal morphogenesis and secretory protein production. There is no reported female phenotype.
Mutation Information
Mutation Type: Targeted
Gene Name: NK-3 transcription factor, locus 1 (Drosophilia)
Gene Symbol: Nkx3-1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation:
Organ Site: Prostate
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x homozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Nkx3.1<tm1Mms>
Donating Investigator: Dr. Cory Abate-Shen

Key Reference: Rajula Bhatia-Gaur, Annemarie A. Donjacour, Peter J. Sciavolino, Minjung Kim, Nishita Desai, Peter Young, Christine R. Norton, Thomas Gridley, Robert D. Cardiff, Gerald R. Cunha, Cory Abate-Shen, and Michael M. Shen. 1999; Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13:966-77. PMID: 10215624 [Pubmed Abstract]