Available Strain Details

Strain Information
Common Strain Name: LSL-p53 R172H (C57BL/6) Pricing and Ordering Information
Strain Nomenclature: B6.129S4-Trp53tm2Tyj/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3

Strain Description: These mice contain a point-mutant allele of Trp53 that can be activated by Cre-mediated recombination. The conditional allele, containing LoxP sites and a transcriptional/translational STOP sequence, is functionally equivalent to a null mutation. This strain was backcrossed to C57BL/6J more than 20 times.
Mutation Information
Mutation Type: Targeted
Gene Name: Transformation related protein 53
Gene Symbol: Trp53
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: C57BL/6
Approx. Generation: 5
Organ Site:
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. SPERM: Sperm was obtained from heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Trp53<tm2Tyj/NCI>
Donating Investigator: David Tuveson

Key Reference: Olive KP; Tuveson DA; Ruhe ZC; Yin B; Willis NA; Bronson RT; Crowley D; Jacks T. 2004. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell 119(6):847-60. PMID: 15607980, MGI Ref ID J:95316 [Pubmed Abstract]

Related Reference: Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, Lolkema MP, Jiang P, Kultti A, Thompson CB, Maneval DC, Jodrell DI, Frost GI, Shepard HM, Skepper JN, Tuveson DA Gut. 2013 Jan;62(1):112-20. doi: 10.1136/gutjnl-2012-302529. Epub 2012 Mar 30. PMID: 22466618 [Pubmed Abstract]