Available Strain Details

Strain Information
Common Strain Name: ROSA-CreER Pricing and Ordering Information
Strain Nomenclature: B6;129-Gt(ROSA)26Sortm1(cre/Esr1)Tyj/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3,C4A,C4B

Strain Description: These mice carry a conditional cre recombinase (Cre-ERT2) allele targeted to the ubiquitously expressed ROSA26 locus (Thumpd3). The estrogen receptor T2 (ERT2) moiety fused to cre retains the recombinase in the cytosol until tamoxifen administration releases this inhibition, thus permitting inducible recombination of LoxP sites.
Mutation Information
Mutation Type: Targeted
Gene Name: gene trap ROSA 26
Gene Symbol: Gt(ROSA)26Sor
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129
Approx. Generation: 21
Organ Site: Various
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is homozygous females x homozygous males. SPERM: Sperm was obtained from homozygous males. When maintained as a live colony, breeder pairs were distributed as homozygotes. Average litter size is 7.
Genotyping Information: Protocol 1: Allele: Gt(ROSA)26Sor<tm1(cre/Esr1)Tyj
Donating Investigator: Dr. Tyler Jacks

Key Reference: Ventura, A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R and Jacks T. 2007. Restoration of p53 function leads to tumor regression in vivo. Nature. 2007 Feb 8;445(7128):606-7. PMID: 17251932 [Pubmed Abstract]

Sponsor: Department of Defense W81XWH-05-1-0265, Howard Hughes Medical Insititute