Available Strain Details

Strain Information
Common Strain Name: Lambda-MYC Pricing and Ordering Information
Strain Nomenclature: C57BL/6N-Tg(Igl-MYC)3Hm/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: Hemizygous mice develop monoclonal B-lineage lymphomas and die between 2-6 months of age. This is a model for human Burkitt Lymphoma.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: Myelocytomatosis oncogene (human)
Transgene Symbol: MYC
Promotor Name: Ig lambda light chain 3' locus enhancer
Promotor Symbol: Igl
Current Genetic Background: C57BL/6N
Approx. Generation: 25
Organ Site: Hematopoietic
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Tg(Igl-MYC)3Hm
Donating Investigator: Dr. Herbert Morse

Key Reference: Kovalchuk AL, Qi CF, Torrey TA, Taddesse-Heath L, Feigenbaum L, Park SS, Gerbitrz A, Klobeck G, Hoertnagel K, Polack A, Bornkamm GW, Janz S, Morse III HC. 2000. Burkitt lymphoma in the mouse. J. Exp. Med. 192:1183-1190. PMID: 11034608 [Pubmed Abstract]