Available Strain Details

Strain Information
Common Strain Name: Msh3 null Pricing and Ordering Information
Strain Nomenclature: B6.129-Msh3tm1Rak/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B

Strain Description: This strain carries a null mutation in the DNA mismatch repair gene Msh3. Cells from mice homozygous for this mutation have only a partial mismatch repair defect. Mice homozygous for this mutation have only a slightly elevated tumor incidence over wild type mice. When combined with Msh6 null mutation, the mice show cancer susceptibility that is similar to that seen in Mlh1 and Msh2 nulls.
Mutation Information
Mutation Type: Targeted
Gene Name: MutS homolog 3
Gene Symbol: Msh3
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.129
Approx. Generation: N10
Organ Site: GI
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Msh3<tm1Rak>
Donating Investigator: Dr. Raju Kucherlapati

Key Reference: Edelmann W, Umar A, Yang K, Heyer J, Kucherlapati M, Lia M, Kneitz B, Avdievich E, Fan K, Wong E, Crouse G, Kunkel T, Lipkin M, Kolodner RD, Kucherlapati R. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Cancer Res. 2000 Feb 15;60(4):803-7. PMID: 10706084 [Pubmed Abstract]