Available Strain Details

Strain Information
Common Strain Name: Langerin-Cre Pricing and Ordering Information
Strain Nomenclature: B6.Cg-Tg(CD207-cre)1Dhka/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B1

Strain Description: When bred onto a strain carrying a homozygous floxed gene, that gene is efficiently excised in virtually all epidermal Langerhans cells. The resulting phenotype depends of which gene is ablated.
Mutation Information
Mutation Type: Transgenic
Gene Name:
Gene Symbol:
Transgene Name: iCre
Transgene Symbol: iCre
Promotor Name: Langerin, human
Promotor Symbol: Langerin
Current Genetic Background: B6.Cg
Approx. Generation: 11
Organ Site: Skin, epidermis, lymph
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x hemizygous males. When maintained as a live colony, breeder pairs were distributed as a hemizgyote (male or female) x wildtype C57BL/6 (male or female). Average litter size is 4-6.
Genotyping Information: Protocol 1: Allele: Tg(CD207-cre)1Dhka
Donating Investigator: Dr. Daniel Kaplan

Key Reference: Kaplan et al. Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells. J Exp Med (2007) vol. 204 (11) pp. 2545-52 PMID: 17938236; PMCID: PMC2118472 [Pubmed Abstract]

Related Reference: Igyarto et al. Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10. J Immunol (2009) vol. 183 (8) pp. 5085-93; PMID: 19801524 [Pubmed Abstract]

Sponsor: K08 AR651092 (to Dan Kaplan), R01 HL66279 and R01 AR44077 (to M.J. Shlomchik)