Available Strain Details

Strain Information
Common Strain Name: Rb1 null Pricing and Ordering Information
Strain Nomenclature: B6.129S2(Cg)-Rb1tm1Tyj/Nci
Animal State: Frozen Embryo
Release Category (Required for MTA form): B3

Strain Description: Mice homozygous for the Rb1tm1Tyj targeted mutation die in utero, apparently from a failure to efficiently produce erythrocytes in the liver. Heterozygous mice develop intermediate lobe pituitary tumors beginning at 8 months of age; C cell tumors of the thyroid are also common in this strain. Retinal tumors, which develop in RB(+/-) humans, have not been observed in this strain.
Mutation Information
Mutation Type: Targeted
Gene Name: Retinoblastoma 1
Gene Symbol: Rb1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.Cg
Approx. Generation: 27
Organ Site: All
Additional Information
Cryopreservation Mating Scheme: The cryopreservation mating scheme is C57BL/6 females x heterozygous males. When maintained as a live colony, breeder pairs were distributed as a heterozygote (male or female) x wildtype C57BL/6 (male or female).
Genotyping Information: Protocol 1: Allele: Rb1<tm1Tyj>
Donating Investigator: Dr. Tyler Jacks

Key Reference: Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. 1992. Effects of an Rb mutation in the mouse. Nature. 359:295-300. PMID: 1406933 [Pubmed Abstract]

Related Reference: Sage J1, Miller AL, PĂ©rez-Mancera PA, Wysocki JM, Jacks T. Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature. 2003 Jul 10;424(6945):223-8. PMID: 12853964 [Pubmed Abstract]

Benjamin T Spike 1, Alexandra Dirlam, Benjamin C Dibling, James Marvin, Bart O Williams, Tyler Jacks, Kay F Macleod The Rb Tumor Suppressor Is Required for Stress Erythropoiesis BO J . 2004 Oct 27;23(21):4319-29. doi: 10.1038/sj.emboj.7600432. Epub 2004 Sep 30. PMID: 15457215 PMCID: PMC524396 [Pubmed Abstract]