Available Strain Details

Strain Information
Common Strain Name: STOCK macroH2A1.2 cKO Pricing and Ordering Information
Strain Nomenclature: STOCK Macroh2a1tm1.1Pobe/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3

Strain Description: Ths is a conditional KO strain, so the mice are effectively wildtype. However, upon induced gene activation, you can expect to observe characteristics similar to NCI Mouse Repository strain 01BQ0 - "Mice are viable and fertile and show no overt signs of sickness. Mice have not been kept for significantly longer than 1 year to date. Homozygous knockout mouse embryonic fibroblasts show signs of genome instability, particularly in female cells. A late onset cancer phenotype cannot be excluded."
Mutation Information
Mutation Type: Targeted
Gene Name: macroH2A.1 histone
Gene Symbol: Macroh2a1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: STOCK
Approx. Generation:
Organ Site: whole body
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The embryo cryopreservation scheme is homozygous males x homozygous females; SPERM: sperm was obtained from homozygous males
Genotyping Information: Protocol 1: Allele: Macroh2a1<tm1.1Pobe>/Nci
Donating Investigator: Dr. Philipp Oberdoerffer

Key Reference: