Available Strain Details

Strain Information
Common Strain Name: miR-10b KO Pricing and Ordering Information
Strain Nomenclature: C57BL/6-Mir10btm1.2Arte/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3,C1

Strain Description: miR-10b is largely dispensable for normal development but critical to tumorigenesis. Loss of miR-10b delays oncogene-induced mammary tumorigenesis and suppresses epithelial?mesenchymal transition, intravasation, and metastasis in a mouse model of metastatic breast cancer (MMTV-PyMT transgenic).
Mutation Information
Mutation Type:
Gene Name: microRNA 10b
Gene Symbol: miR-10b
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: C57BL/6
Approx. Generation:
Organ Site: Whole body
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryopreservation mating scheme is C57BL/6 females x homozygous males. SPERM: Sperm was obtained from homozygous males.
Genotyping Information: Protocol 1: Allele: Mir10b<tm1.2Arte>
Donating Investigator: Dr. Li Ma

Key Reference: Kim J1, Siverly AN1, Chen D1, Wang M1, Yuan Y2, Wang Y2, Lee H1, Zhang J1, Muller WJ3, Liang H2, Gan B1, Yang X4, Sun Y5, You MJ6, Ma L7. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways., Cancer Res. 2016 Nov 1;76(21):6424-6435., PMID: 27569213 [Pubmed Abstract]