Available Strain Details

Strain Information
Common Strain Name: B6.Cg-macroH2A1.2 KO Pricing and Ordering Information
Strain Nomenclature: B6.Cg-Macroh2a1tm1.2Pobe/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B3

Strain Description: Mice are viable and fertile and show no overt signs of sickness. Mice have not been kept for significantly longer than 1 year to date. Homozygous knockout mouse embryonic fibroblasts show signs of genome instability, particularly in female cells. A late onset cancer phenotype cannot be excluded.
Mutation Information
Mutation Type: Targeted
Gene Name: macroH2A.1 histone
Gene Symbol: Macroh2a1
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6.Cg
Approx. Generation:
Organ Site: whole body
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: Cryopreservation mating scheme is homozygous males x homozygous females. SPERM: sperm was obtained from homozgyous males. However, per the donating investigator's lab, homozgyous females may show reduced fertility. In this event, mate homo males x het females. No other husbandry issues have been observed. Sperm was obtained from homozgyous males.
Genotyping Information: Protocol 1: Allele: Macroh2a1<tm1.2Pobe>/Nci
Donating Investigator: Dr. Philipp Oberdoerffer

Key Reference: UNPUBLISHED [Pubmed Abstract]