Available Strain Details

Strain Information
Common Strain Name: Bloom homolog mutant Pricing and Ordering Information
Strain Nomenclature: B6;129S-Blmtm3Brd/Nci
Animal State: Frozen Embryo & Frozen Sperm
Release Category (Required for MTA form): B2

Strain Description: Increased mitotic recombination occurs in cells from Blm-deficient mice, leading to increased rates of LOH (loss of heterozygosity). Meiotic recombination is normal. A variety of malignant and benign tumors develop in Blm-deficient mice, usually after one year of age. The tumor spectrum includes lymphomas, sarcomas and carcinomas. This strain provides a model for Bloom syndrome in humans as well as a model to study genomic instability. In addition the increased rate of LOH coupled with the late tumor onset make this strain valuable in identifying recessive cancer mutations through somatic genetics.
Mutation Information
Mutation Type: Targeted
Gene Name: Bloom syndrome homolog
Gene Symbol: Blm
Transgene Name:
Transgene Symbol:
Promotor Name:
Promotor Symbol:
Current Genetic Background: B6;129S2
Approx. Generation: Homo
Organ Site: All
Additional Information
Cryopreservation Mating Scheme: EMBRYOS: The cryo mating scheme is homozygous females x homozygous males. SPERM: Sperm was obtained from homozgyous males. When maintained as a live colony, breeder pairs were distributed as homozygotes.
Genotyping Information: Protocol 1: Allele: Blm<tm3Brd>
Donating Investigator: Dr. Allan Bradley

Key Reference: Luo G, Santoro IM, McDaniel LD, Nishijima I, Mills M, Youssoufian H, Vogel H, Schultz RA, Bradley A.Cancer predisposition caused by elevated mitotic recombination in Bloom mice. 2000 Nat Genet 26:424-9. PMID: 11101838 [Pubmed Abstract]