A National Resource Tools & Resources for Researchers
We offer access to a suite of advanced biomedical technologies, provide selected science and technology services, and maintain vast repositories of materials for use by the research community.
Biomedical investigators are invited to leverage Frederick National Laboratory resources and technology to meet their research goals. Learn more about the advanced biomedical technologies, technical services, and data and specimen repositories available to the research community.
Most resources listed below are available for researchers at no cost or for a nominal fee.
Contact the Partnership Development Office for more information at PDO@nih.gov
Technical Services Program
Datasets & Computational Tools
Clinical Trials Reporting Program
Comprehensive database on all interventional NCI-funded clinical trials to help identify gaps and duplicate studies in clinical research, facilitate clinical trial prioritization, and standardize trial data capture and sharing.
SIV/SHIV Barcode Analysis Tool
An R-script with associated support files to demultiplex next-generation sequencing and determine the abundance of individually barcoded SIV/SHIV viral lineages.
MHL Immunohistochemistry Database
The Molecular Histopathology Laboratory created this database to provide the specifics of hundreds of chromogenic and fluorescent immunohistochemical assays culled from decades of prior service requests. The database shows recommended methods including validated control tissue(s) for targeted antibodies.
DAVID: Database for Annotation, Visualization, and Integrated Discovery
DAVID provides a comprehensive set of functional annotation tools to help understand the biological meaning behind large gene lists. Powered by the DAVID Knowledgebase, it integrates multiple sources of functional annotations. The database provides several analytical tools including functional annotations, gene ID conversion, ortholog tool, gene classification, and batch gene name translations.
CRISPR & gene-editing tools
The dbGuide is a database of validated guide RNA sequences that have been used in gene-editing experiments in human and mouse cells.
The sgRNA Scorer is a web tool that identifies putative sites and assigns a predicted activity based on our new support vector machine model.
Cancer Research Data Commons
Researchers can access cloud-based repositories with various cancer data sets. Our Center for Technical Operations Support helped develop the infrastructure enabling researchers to use a variety of analytical and visualization tools across cancer research data.
- Cancer Data Service
- Clinical and Translational Data Commons
- Genomic Data Commons
- Imaging Data Commons
- Integrated Canine Data Commons
- Proteomic Data Commons
Imaging Services & Resources
National Cryo-Electron Microscopy Facility
User facility enabling access to advanced microscopes capable of supporting high-resolution cryo-electron microscopy studies.
The Cancer Imaging Archive
Publicly accessible resource that hosts a large archive of medical images of cancer.
Volume-EM tools
Empanada and Mitonet are tools for panoptic segmentation of organelles in 2D and 3D electron microscopy images.
Related Research & Technology Programs
Models & Cell Lines
DCTD Tumor Repository
Cryopreserved in vivo-derived tumors and in vitro-established tumor cell lines, including the NCI-60 cell line and mouse tumors from the Jackson Laboratory.
Human Cancer Models Initiative Catalog
Community resource of a large number of in vitro, next-generation cancer models.
Patient-Derived Models Repository
Established, quality-controlled PDMs clinically-annotated with molecular information available in an easily accessible database.
Related Research & Technology Programs
Drug Discovery
HIVGenoPipe
A bioinformatics pipeline to more accurately detect HIV drug resistance and potentially improve the quality of antiretroviral therapies for people living with HIV. Scientists in our Applied and Developmental Research Directorate developed HIVGenoPipe to process genome sequence data in search of genetic variations indicative of drug resistance. This is an open-source software freely available for use by scientists and clinicians.
CLIA Molecular Diagnostics
High-complexity assays in niche areas not suitable for higher volume clinical testing, and access to cutting-edge technologies and specialized services.
Complex tumor spheroid models
Leverage these mechanistic studies that evaluate drug activities using a range of cell-based models. More data is available within each publication.
Compound screening
Documentation, publications, and datasets from state-of-the-art, automated and manual approaches to evaluate candidate molecules and existing therapeutics as single and combination treatments. Includes resources related to the NCI-60 Human Tumor Cell Lines Screen.
Nanotechnology
The Nanotechnology Characterization Laboratory offers multiple collaboration mechanisms, depending on researcher needs, including a free characterization program, fee-based research and development collaborations, and select fee-for-service assays.
Related Research & Technology Programs
Reagents & Biological Products
Antibody Portal
Access to a large number of standardized renewable affinity reagents (to cancer-associated targets) and accompanying characterization data.
BRB Preclinical Biologics Repository
Reagent repository of human cytokines and growth factors, monoclonal antibodies (anti-human and anti-murine), and recombineering reagents.
HIV Biological Products
Services for investigators, including the production and purification of virus materials, development of infected cell lines, and provisioning of key reagents.
Natural Products Repository
80,000 plant samples, 20,000 marine invertebrates and marine algae samples, and 16,000 microbes samples.
Protein production materials
New technologies and materials generated at the Protein Expression Laboratory are available to academic researchers.
RAS Reagents and Tools
Researchers with the NCI RAS Initiative have developed a variety of unique reagents, assays, and tools for use.
Learning & Reference Resources
cGMP Training
Training slides with information on various topics relating to current Good Manufacturing Practices.
Project Management Night Out Seminar Series
Bi-monthly in-person event with Hood College providing educational and networking opportunities for project managers.
Scientific Standards
A central hub to develop, deposit and share standards and references in biological research.
Related Research & Technology Programs
Scientific Standards Hub
Disease-specific services
COVID-19
Researchers can access SARS-CoV-2 serology materials, PBMCs, and serum.
HPV
Request HPV Serology materials, including the Serology Reference Standard & Proficiency Panel.
Tuberculosis
Through the Technical Service Program, FNL investigators measure levels of Mycobacterium tuberculosis DNA in nonhuman primate tissue specimens.
HIV/SIV
Through the Technical Services Program, researchers can access many at-cost services for HIV/SIV research with the AIDS and Cancer Virus Program. Additionally, FNL investigators offer further tools and resources, including technology they've developed for studies.
- Viral Integration Site Analysis (VISA) for HIV studies
- Next-generation sequencing analysis of barcoded SIV, SHIV, or HIV
- HIV/SIV Single Genome Amplification and Sequencing
- Lineage-specific Next Gen Multiplex In Situ Hybridization for HIV or SIV RNA and DNA
- Quantitative assessment of HIV or SIV viral DNA in laser capture microdissected immune cells
- Quantitative Assessment of Lymphoid Tissue Fibrosis
- Novel CD4+ T Cell Specific Immunohistochemistry Detection and Analysis
- Cellular or Tissue SIV/SHIV RNA and DNA testing
- Plasma or CSF SIV/SHIV RNA measurements
- SIV/SHIV Barcode Analysis Tool
- HIVGenoPipe
