Laboratory of Cell Molecular Biology

Overview

The Laboratory of Molecular Cell Biology conducts research in collaboration with scientists at the National Institute of Allergy and Infectious Diseases to understand the biology of T cell activation and HIV persistence. 

We support the Laboratory of Immunoregulation by developing and performing quantitative and qualitative polymerase chain reaction assays. 

Innovations

Evidence for HIV-1 replication in patients with undetectable plasma virus receiving highly active antiretroviral therapy. Recent data obtained with autopsy samples taken from patients with undetectable plasma virus confirms the presence of HIV RNA in spleen, lymph node, colon, brain, kidney and liver suggesting persistence of viral replication in those organs. 

Focus

HIV persistence 

  • Study HIV replication in organs of patients with undetectable virus in blood. 

T cell activation 

  • Evaluate the stimulation of LZTFL1 during T cell activation and its role in immune synapse.