Retrovirus-Cell Interaction Section

Overview

and potential of cellular immune control of AIDS virus infection focusing on SIV infection of rhesus macaques as a model system.  Approaches employed include molecular engineering of T cells for expression of antiviral T cell receptors and functional activities, along with receptors to direct trafficking of infused cells to relevant tissues in adoptive cellular immunotherapy.

Focus

Cellular engineering 

  • Engineered adoptive cell therapy to understand the potential and limits of cellular immune control of AIDS virus infection. 

  • Optimize molecular engineering of primary macaque lymphocytes to confer desired in vivo antiviral properties.