The Advanced Cryo-Electron Microscopy Technology Group explores emerging imaging platforms and develops methodologies, focusing on projects with the potential to make cryo-EM a more widely accessible technique.
The team focuses on single-particle analysis and cryo-electron tomography. Our group aims to push resolution limits on our 200 kV CryoARM microscope to compare its performance to the more popular 300 kV microscopes. Our structure-determination methods are initially developed on standard cryo-EM specimens, such as beta-galactosidase, and later applied to more biologically relevant samples, especially where high-resolution information is needed to provide mechanistic insights. Ultimately, the goal is to sufficiently streamline the process to efficiently obtain high-resolution cryo-EM structures for a broad range of targets.
We work with the National Cryo-Electron Microscopy Facility to improve its services and support provided to the research community.