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  A new study used an innovative method to track anatomic origin of rebound of HIV-like virus.
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  Analysis of paired blood biopsies, tumor tissue as biomarkers for cancer to be presented at ASCO
  FNL scientists will present a recent study comparing mutations found in paired tuors and ctDNA at the 2026 American Society for Clinical Oncology Annual Meeting.
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NIH partnership establishes new Gene Therapy Immunology and Standards Laboratory
A new initiative aims to standardize gene therapy research, speeding the path to clinical trials and new treatments.
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  Save the date Oct 7-9, 2026
  
  6th RAS Initiative Symposium
  Join us for the 2026 RAS Initiative Symposium.
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  Importance of innovation Within FNL, innovation plays a pivotal role in delivering new and enhanced technologies that empower us to tackle essential scientific inquiries, enhance our services, and ultimately contribute to the wellbeing of patients.
  Vladimir Popov, Ph.D., MBA
- Scientific Series
  Sep 9, 2026
  
  2026 Technology Showcase
  Free, in-person event with networking and one-on-one partnering opportunities.
American Association for Cancer Research Annual Meeting
Preclinical data on potential treatment for RAS-driven cancers to be presented at AACR26
Studies on BBO-10203 and BBO-11818 will be presented in San Diego.
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FNL Global Clinical Research Educational Modules
Learn about challenges in clinical research during emergency infectious disease outbreaks and strategies to overcome them.
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Brilliant teamwork The team here is made up of brilliant scientists. Coming from a diverse research background myself, it’s inspiring to be in a room where everyone contributes something unique. I feel truly privileged to be part of it.
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About FNL
Did you know?

About 30% of all human cancers are driven by mutations of the RAS family of genes. The RAS Initiative endeavors to better understand the RAS oncogene and discover its vulnerabilities to treat RAS-related cancers.

Publications

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Below you'll find a list of all our scientific publications.

Only authors from the Frederick National Laboratory for Cancer Research are displayed.

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Directorate / Lab / Affiliation

AIDS Monitoring Laboratory

AIDS and Cancer Virus Program

Advanced Biomedical Computational Science

Advanced Cryo-Electron Microscopy Technology Group

Animal Diagnostics Laboratory

Animal Research Technical Support

Antibody Characterization Laboratory

Applied and Developmental Research Directorate

Basic Science Program

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Mouse Modeling and Cryopreservation

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National Cryo-Electron Microscopy Facility

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Pharmacokinetics and Drug Analysis Group

Protein Expression Laboratory

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Radiochemistry Support Group

Retroviral Evolution Section

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Small Animal Imaging Program

Tissue Analysis and Retroviral Protein Chemistry Core

Vaccine Clinical Materials Program

Vaccine, Immunity, and Cancer Directorate

Viral Evolution Core

Viral Oncology Section

Viral Persistence Section

Virus Isolation and Serology Laboratory

May1

2026

New concepts in drug discovery (2026): Drug residence time

Curr Opin Struct Biol

PMID 42172734

Nussinov R, and 1 more

Basic Science Program

May1

2026

Nonhuman primate models of HIV reveal reservoir dynamics and promising interventions

Curr Opin HIV AIDS

PMID 42139119

Keele BF

AIDS and Cancer Virus Program › Retroviral Evolution Section

May1

2026

Pediatric SARS-CoV-2 outcomes study (PECOS): 12-month longitudinal analysis of post-COVID symptoms in infected versus uninfected participants

Pediatr Res

PMID 42070008

Mateja A, Wolff MT, Weyers S, *PECOS study team - Chu E, Rubenstein K, and 14 more

Clinical Monitoring Research Program

May1

2026

PEGylation strategies for enhanced nanoparticle delivery to tumor-associated immune cells

Bioeng Transl Med

PMID 42272952

Patel N, Gower T, and 6 more

Laboratory Animal Sciences Program › Laboratory Animal Medicine, Small Animal Imaging Program

May1

2026

Pervasive Cas9 expression driven by mammalian promoter activity in E. coli affects representation of CRISPR sgRNA libraries

Commun Biol

PMID 42120907

Guest MR, Chari R, and 4 more

Laboratory Animal Sciences Program › Genome Modification Core

May1

2026

Predictors of psychosocial burden in parents of food allergic children

Ann Allergy Asthma Immunol

PMID 42155862

Callier V, Mateja A, and 6 more

Clinical Monitoring Research Program

May1

2026

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass

Biochem J

PMID 42017331

Simanshu DK, and 1 more

Cancer Research Technology Program

May1

2026

Spatial resolution of the metastatic osteosarcoma tumor microenvironment using immunolabeling across murine, canine and human lung

J Transl Med

PMID 42163361

Butcher DO, Edmondson EF, and 8 more

Laboratory Animal Sciences Program › Molecular Histopathology Laboratory

May1

2026

Targeting EP2/EP4-driven expansion of suppressive VSIG4(high) macrophages overcomes immunotherapy resistance in colorectal cancer

Cell Rep

PMID 42213779

Nussinov R, and 25 more

Basic Science Program

Apr1

2026

Activation of an adaptive antitumor immune response by the polymeric fluoropyrimidine CF10 involves TS/Top1 dual targeting

Biomed Pharmacother

PMID 42019467

Cedrone E, Dobrovolskaia MA, and 5 more

Cancer Research Technology Program, Nanotechnology Characterization Laboratory

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Frederick National Laboratory for Cancer Research is operated by Leidos Biomedical Research, Inc. for the National Cancer Institute.

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