• Research Category Research & Development Services & Subcontracts
• Vendor Name Leidos Biomedical Research, Inc.
• Solicitation Number S23-012
• NCI OA Contract Number 75N91019D00024 – NCI-FFRDC

Description

1. Provide support to identify members of neutralizing antibody lineages for a specified disease target, observe and analyze antibody affinity maturation in humans and experimental animals. Results will be provided in the form of figures or reports using templates/formats as agreed upon by the VRC and Subcontractor to support future publication. The following tasks will be performed in support of this requirement:
1.a. Repertoire Analysis: basic bioinformatic processing of NGS samples, including per animal germline gene analysis, germline annotation of all transcripts and summary statistics of the sampled antibody repertoire
1.b. Phylogenetic analysis: identification of transcripts from a specific lineage and phylogenetic analysis of the lineage of NGS samples

2. The Subcontractor will provide Cryo-EM support to include microscope time using samples provided by VRC. Support will include producing Cryo-EM images for analysis by VRC investigators. Images and image data files will be provided to the VRC.

Proposal Instructions

OFFERS MUST BE SUBMITTED ELECTRONICALLY IN EITHER SEARCHABLE ADOBE ACROBAT, MICROSOFT WORD, OR MICROSOFT EXCEL FORMATS AS APPLICABLE. SAVED FILES MUST NOT EXCEED 15 MB IN SIZE; THIS MAY REQUIRE THAT A DOCUMENT BE BROKEN INTO TWO OR MORE SEPARATE FILES.
ALL OFFERS MUST BE RECEIVED BY 4PM ET, 12/15/2022. OFFERS SHALL BE SUBMITTED TO DAN MCDOWELL AT DANIEL.MCDOWELL2@NIH.GOV.
All offer submissions must be clearly identified to include the Offeror’s name, Principal Investigator’s name (or Project Manager’s name), and Solicitation/RFP Number.
Late offers will not be considered for award.
For the full solicitation, please contact Daniel McDowell at daniel.mcdowell2@nih.gov