Posted 3/15/2023
Severe forms of neurofibromatosis linked to disruptions in a protein partnership New research by Frederick National...
Posted 2/15/2023
To celebrate International Women and Girls in Science Day, we co-hosted a panel discussion on Feb. 10 with Woman to...
Posted 11/15/2022
The Biopharmaceutical Development Program (BDP) at Frederick National Laboratory is engineering cells into cancer...
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Though rare, HIV leads to blood cancers
Laboratory Animal Sciences ProgramPosted 10/13/2021HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.
Scientists have long known that HIV contributes to several cancers by weakening the immune system’s ability to fend off cancer-causing infections like Kaposi sarcoma–associated herpesvirus and Epstein-Barr virus. However, this latest study, published in Science…
Coronavirus spike protein deteriorates during storage, but it can be restored
National Cryo-EM FacilityPosted 10/6/2021The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed.
The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under conventional storage conditions of…
Like a natural: Scientists seek compounds to target and study rare skin cancer
Basic Science ProgramPosted 9/22/2021A team of scientists has gone fishing, but they’re interested in more than the bounty of the seas: They’ve also cast out nets on land. And they’ve never left the laboratory.
Their “nets” are high-powered chemical and biological analyses. The team, a group of cancer biologists, dermatologists, biochemists, natural product chemists, and bioinformaticians, hasn’t been…
Manufacturing and quality assurance expertise by Frederick National Laboratory supports NCI’s pioneering cancer immunotherapy program
Posted 9/15/2021A grim statistic is driving Steven Rosenberg’s mission to find new cancer treatments—and his partnership with Frederick National Laboratory (FNL) to do so.
“Every year in the United States, about 600,000 people die of cancer, 90% of whom die of the solid epithelial cancers,” said Rosenberg, the M.D., Ph.D., chief of the National Cancer Institute’s (NCI) Surgery Branch,…
Technical Service Program provides researchers worldwide with access to unique services
Partnership Development Office, AIDS and Cancer Virus Program, Nanotechnology Characterization Laboratory, Laboratory Animal Sciences ProgramPosted 9/9/2021The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program.
The Technical Services Program gives investigators worldwide access to some of FNL’s…
In cancer first: Two heads are better than one
Basic Science ProgramPosted 9/1/2021Their study started to unravel the riddle of how cancers spread, demonstrating that tumors are comprised of different types of cells, or heterogeneous. Up to this point it was thought that cancer cells in a tumor were identical to each other.
The work conducted by husband-and-wife Isaiah (Josh) Fidler, D.V.M., Ph.D., and Margaret Kripke, Ph.D., in Frederick would…
Collaborative seroprevalence study highlights Protein Expression Laboratory’s capabilities
Protein Expression LaboratoryPosted 8/25/2021In a recent study that sought to measure antibody prevalence in participants who had not previously been diagnosed with a SARS-CoV-2 infection, a team of National Institutes of Health researchers reported that for every person diagnosed with COVID-19 in the spring and summer of 2020, it’s estimated that five additional people infected with the virus went undiagnosed. This…
Second annual ATOM summer training program empowers and equips students
Cancer Data Science InitiativesPosted 8/24/2021Six graduate students from Butler University and Nova Southeastern University completed a virtual 10-week summer training program with the Accelerating Opportunities for Therapeutics in Medicine (ATOM) Consortium at the end of July. Their efforts are the latest part of ATOM’s mission to put accelerated, computer-based pharmaceutical discovery in the hands of the scientific…
Risk factor identified for disease disproportionately affecting African Americans
Basic Science ProgramPosted 8/9/2021Frederick National Laboratory (FNL) scientists and their colleagues have identified a genetic risk factor for a dangerous blood pressure disorder in pregnant women of African descent, who are three times as likely to develop the disorder as White women.
The scientists reported in the June issue of the American Journal of Kidney Diseases that when mothers of African descent…
Newly published metadata standards for biological imaging aim to make data sets more accessible
Posted 8/9/2021Meta tags are used on web pages. Metadata is added to photographs. Both help people find, use, and reuse these digital assets. Scientists say the same is needed for image data in biology, and urgently so.
“A single imaging data set could be a thousand images,” said Frederick National Laboratory imaging scientist Kedar Narayan. “Someone might say they don’t want the full…
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