Posted 4/5/2024
The first conference held under the auspices of Frederick National Laboratory’s (FNL’s) Scientific Standards Hub , an...
Posted 1/25/2024
Technologies invented and patented by researchers at the Frederick National Laboratory for Cancer Research are on...
Posted 1/9/2024
Research led by the Frederick National Laboratory for Cancer Research (FNL) and Gilead Sciences shows the potential for...
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FNL collaborates with FDA to establish best practices for single-cell RNA sequencing
Bioinformatics and Computational SciencePosted 3/10/2021Researchers from the Sequencing Facility and Biomedical Informatics and Data Science Directorate at the Frederick National Laboratory (FNL) collaborated with the U.S. Food and Drug Administration (FDA) and other research centers across the U.S. to conduct a benchmark study establishing best practices for high-throughput single-cell RNA sequencing.
The study, published in…
The Cancer Imaging Archive posts COVID-19 imaging data to benefit community
Posted 2/24/2021Publicly available data sets related to COVID-19 are appearing in an unexpected place—the Cancer Imaging Archive (TCIA), a project of the Division of Cancer Treatment and Diagnosis of the National Cancer Institute.
Since the start of the pandemic, researchers around the world have been racing to learn as much as possible about the virus—how it spreads, how to diagnose and…
New directorate expands serology capabilities
Vaccine, Immunity, and Cancer DirectoratePosted 2/23/2021As the Frederick National Laboratory for Cancer Research (FNL) expands its serology efforts in response to the COVID-19 pandemic, the biomedical research institution formed a new section dedicated to those efforts and the evaluation and standardization of immune responses to vaccines, infections and cancer.
Establishment of the Vaccine, Immunity, and Cancer Directorate…
February Biotech Connector highlights progress in liquid biopsies
Partnership Development Office, Molecular Characterization LaboratoryPosted 2/9/2021On February 25, the Biotech Connector series will highlight exciting research on liquid biopsies with two talks by local investigators. Liquid biopsies are highly sensitive blood tests that can detect fragments of tumor DNA, also known as circulating tumor DNA (ctDNA), in the blood—providing critical information about the tumor without an invasive tumor biopsy.
You can…
RAS Initiative reveals cancer-causing protein’s primary membrane orientation
RAS InitiativePosted 2/8/2021RAS proteins reside on the inner cell membrane, where they use a lure like a fly fisherman to bring partner proteins to the membrane, leading to cell growth. Researchers at the Frederick National Laboratory for Cancer Research (FNL) used multiple experimental techniques along with a computer simulation to understand how KRAS functions at the inner side of the cell membrane and…
Frederick National Laboratory helps meet pressing need for accurate coronavirus antibody testing
Protein Expression LaboratoryPosted 2/3/2021The Frederick National Laboratory (FNL) is providing scientists across the country with a key antigen used in antibody tests for the coronavirus after finding that the antigen is exceptionally sensitive and can be made rapidly and at low cost. This helps meet a pressing need for accurate testing.
The antigen, a protein, is used in blood tests to show whether a person…
Antibody manufactured at Frederick National Laboratory receives FDA approval to treat Ebola virus disease
Vaccine Clinical Materials ProgramPosted 2/2/2021The Food and Drug Administration has approved a monoclonal antibody developed at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, for the treatment of Ebola virus in adults and children. The approval was granted in late December.
The antibody, called mAb114 or ansuvimab, is…
Frederick National Laboratory triples CAR T cell manufacturing capacity for cancer clinical trials
Biopharmaceutical Development ProgramPosted 1/21/2021The Frederick National Laboratory (FNL) has begun building out new production space that will triple its capacity to manufacture cell and gene therapies to support cancer clinical trials.
BDP manufacturing staff use a Miltenyi Prodigy for CAR T-cell production. Incubators seen in the background are available for non-Prodigy based cell therapy production.
The…
Frederick National Laboratory and Georgetown University present scientific lecture series in 2021
Posted 1/12/2021The Frederick National Laboratory for Cancer Research and Georgetown University will present the second annual Scientific Partners Distinguished Lecture Series featuring five seminars by leading scientists from both organizations. The 2021 series is open to the public and will be completely virtual. Participation details for each seminar will be announced prior to the event…
Clones complicate a cure and pose problems for people with HIV
AIDS and Cancer Virus ProgramPosted 12/21/2020A new advance in our understanding of HIV comes from what Steve Hughes, Ph.D., calls “an odd observation.”
Certain people living with HIV had only partially suppressed levels of virus in their blood despite being on effective antiretroviral therapy (drugs used to manage HIV). At first, an explanation seemed like it would be simple—but it wasn’t.
Doctors usually…
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