Posted 4/5/2024
The first conference held under the auspices of Frederick National Laboratory’s (FNL’s) Scientific Standards Hub , an...
Posted 1/25/2024
Technologies invented and patented by researchers at the Frederick National Laboratory for Cancer Research are on...
Posted 1/9/2024
Research led by the Frederick National Laboratory for Cancer Research (FNL) and Gilead Sciences shows the potential for...
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Scientists to present multidisciplinary studies at AACR Annual Meeting
Partnership Development Office, Molecular Characterization Laboratory, Meet us at AACRPosted 4/6/2022
Investigators from the Frederick National Laboratory for Cancer Research will share their latest work regarding the use of pre-clinical models for compound screening and tumor characterization,
bioinformatics and technology initiatives, among other topics, at the American Association for Cancer Research 2022 Annual Meeting.
More than 30 abstracts by Frederick…
STAR TREC takes on reproducibility, standardization, and better science
Scientific Standards Hub, Partnership Development Office, Leonard Freedman, Ph.D.Posted 4/4/2022An initiative at Frederick National Laboratory for Cancer Research (FNL) is confronting what’s been dubbed the scientific “reproducibility crisis.”
The effort, called STAR TREC (the Standards References and Training Research Committee), seeks to help the scientific community address reproducibility issues and aims to spur dialogue about better standards in science.…
New study finds classical RAS proteins are not essential for RAF inhibitor-induced paradoxical ERK activation
RAS InitiativePosted 4/1/2022The classical RAS family of proteins functions as molecular switches at the cell’s plasma membrane where it cycles between an active and inactive state. The active state initiates a cascade of events that promote downstream signaling to regulate cellular functions, such as cell proliferation.
Mutations and dysregulation of the RAS-RAF-MEK-ERK signaling pathway are among…
Second HIV patient appears to have cured herself with natural immunity
Basic Science Program, Mary Carrington, Ph.D.Posted 3/15/2022Frederick National Laboratory scientists were part of a multi-institutional collaboration that has identified a second patient whose natural immune response to HIV infection appears to have cured her of the disease, raising the question: Can this be replicated?
Only three other patients have ever been declared fully cured, but each of these outcomes was accomplished…
Cancer researchers invited to apply for new cryo-EM training program
National Cryo-Electron Microscopy Facility, NCEF Cryo-EM Training ProgramPosted 3/9/2022The Frederick National Laboratory will host a new training program in Frederick, Maryland, September 12-16 for cancer researchers who want to build expertise in cryo-electron microscopy (cryo-EM).
Cryo-EM is a microscopy technique where samples are flash-frozen and bombarded with electrons to generate images. The resulting high-resolution images are helping cancer…
Columbia University students employ AI to predict chemical properties in hands-on drug discovery project
Cancer Data Science Initiatives, Partnership Development OfficePosted 2/28/2022Seven Columbia University graduate students recently completed drug discovery projects at the Frederick National Laboratory for Cancer Research (FNL) as part of their fall 2021 semester. Since 2020, 40 Columbia University students have completed projects with the FNL for their master’s degree coursework.
The projects represent a partnership between Columbia University’s…
Lack of reaction to the COVID-19 shot doesn’t mean it’s not working
Posted 2/23/2022You may have had a sore arm, felt tired, or had a headache. Maybe you ran a slight fever. You might have heard these things happen because your COVID-19 shot is working as it should. On the other hand, a lack of side-effects does not point to vaccine failure, according to a new study.
The relationship between a reaction to COVID-19 vaccines and the strength of antibody…
Team connects genetic variant to poor outcomes after certain cancer treatment
Basic Science ProgramPosted 2/17/2022Scientists have identified a genetic variant that can predict whether immunotherapy drugs called immune checkpoint inhibitors, used to treat cancer, might fail in certain patients.
The team’s findings, which appear in Lancet Oncology, point to HLA-A*03, an allele (a form of a gene) found on chromosome 6 of human DNA. The presence of HLA-A*03 in cancer patients’ DNA was…
Three Frederick National Laboratory teams awarded 2021 NIH director’s awards
Protein Expression Laboratory, Clinical Monitoring Research Program, Terri BrayPosted 2/14/2022The National Institutes of Health (NIH) awarded three Frederick National Laboratory teams with NIH Director’s Awards for innovative approaches to COVID-19-related research that advances knowledge and enhances health.
“It is a tremendous honor for three Frederick National Laboratory teams to be nominated by three distinct entities within NIH. I am grateful to the NIH for…
Women in Science Speak
Partnership Development OfficePosted 2/11/2022Feb. 11 was International Women and Girls in Science Day. To celebrate, we co-hosted a panel discussion with Woman to Woman Mentoring where successful women in science discussed their chosen career paths, allyship and mentorship in science and strategies for advancement.
Keynote speaker
Carla Williams, Ph.D.
Associate Professor of Medicine &…
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