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Amanda Corbel

Manager, Communications Office

Email amanda.corbel@nih.gov or call 301-228-4489 for all media related questions.

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Molecular Characterization Laboratory

ASCO oral presentation, posters to explore use of liquid biopsy in rare cancers

Biswajit Das, Ph.D., MoCha associate director, will present this study in an oral abstract session on Friday, May 30 at 4:45 CT in Hall D1 of the convention center. Using ctDNA to classify tumor types In another study, scientists evaluated the ctDNA to determine fragmentation patterns, which are unique to each tumor type and can help more precisely identify the cancer. The fragment-based model accurately identified the cancer type in nearly 100% of samples that were definitively diagnosed in pathology. About 5% of the time, patient samples are determined “not otherwise specified (NOS)” in pathology reports. The tumor’s origin is unknown, or the sub-type of a cancer cannot be determined. Using the fragmentation data, Peter Wu and colleagues accurately identified sub-types of pancreatic and ovarian cancer, indicating ctDNA could be used as a tool to more precisely classify tumor types. MoCha Director Chris Karlovich, Ph.D., will present the study in POSTED: 5/28/2025
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