HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.…

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly…

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FNL HIV Investigator Brandon Keele Shapes Peer Research with Multiple Seminal and Highly Cited Papers

Posted 2/2/2020
Discoveries by AIDS researcher Brandon F. Keele, Ph.D. have not only put him on the leading edge of research to prevent and treat HIV infection. He’s also influenced the work of his peers.

Keele, a principal investigator and senior principal scientist in the AIDS and Cancer Virus Program at the Frederick National Laboratory was named a Highly Cited Researcher by…

National Lab Team Harnesses Metabolism for Therapy in Pancreatic Cancer

Posted 1/27/2020
A team led by Frank McCormick, Ph.D., FRS, D.Sc. (Hon), RAS National Program Advisor at the Frederick National Laboratory for Cancer Research and professor emeritus at UCSF Helen Diller Family Comprehensive Cancer Center, has found a new vulnerability in pancreatic cancer and revealed a potential strategy for combating one of the most treatment-resistant malignancies.

RAS Initiative has replaced mystery with momentum

Posted 1/17/2020
It started as an ambitious shot in the dark, a plunge into the scientific unknown. But the National Cancer Institute RAS Initiative has quickly helped to reverse the field’s perspective on a problem long considered unsolvable.

When the RAS Initiative was founded in 2013, researchers studying mutated RAS proteins (cancer-causing variants of the three common RAS…

Cell Division Rates and Cancer Risk Decelerate in Very Old People, but Not in Very Old Mice

Posted 1/13/2020
While advancing age is the most important risk factor for cancer, the incidence of the disease decreases in very elderly people.

A study led by Johns Hopkins University provided a potential explanation for this puzzling drop in new cancer diagnoses among the oldest and most rapidly growing segment of western population: that cell division rates – and thus…

Survivor Brings Drive and Rare Personal Perspective to Ebola Virus Disease Reasearch

Posted 1/8/2020
Dr. Ian Crozier Draws on His Own Experience to Inform Studies in Humans and in the Lab

Surviving very severe Ebola virus disease made it clear to Ian Crozier, M.D., that there was a gap to bridge between clinicians caring for patients at outbreak bedsides and the bench scientists peering into fundamental mechanisms of disease to develop prevention and treatment…

Frederick National Laboratory Part of SC19 “Best Paper” Team

Posted 1/6/2020
A multidisciplinary team including members of the Frederick National Laboratory has been recognized with the “Best Paper” award at SC19, a prestigious international conference for high-performance computing, networking, storage, and analysis. Of the 344 papers submitted to SC19, only 87 were accepted, and just one was named Best Paper.

The research team spent…

Nivolumab Precision Medicine Sub-study Ends with Encouraging Results

Posted 12/30/2019
FREDERICK, Md. -- The cancer drug nivolumab may be effective against more types of tumors than previously thought, according to results from a sub-study of the National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH), the world’s largest precision medicine trial.

Nivolumab (marketed as Opdivo) is currently approved to treat several cancers,…

FNL is a Partner in Project that Aims to Standardize Measurement of Genetic Blood Tests to Track Cancer

Posted 12/19/2019
FREDERICK, Md. – Frederick National Laboratory for Cancer Research is a key partner in a collaboration that aims to standardize the assessment of genetic tests that use blood samples to track cancer in hospitals and laboratories across the United States.

The Foundation for the National Institutes of Health (FNIH) started the project earlier this year as part of…

Ebola Study a Source of Hope and Humanity During Violence, Danger, and Disease

Posted 12/16/2019
FREDERICK, Md. -- “Sure, it’s easier than doing research in more isolated places, say Antarctica, or outer space—but that does not make it easy for those on the ground. Sometimes densely populated areas pose problems of their own. Not everyone agrees on the need, the presence of so many ‘outsiders,’ or on the approach taken. People were attacked. Research sites were burned.”…

Research Team Finds TTK Inhibitor Kills Lung Cancer Cells and Tumors in Mice

Posted 12/12/2019
FREDERICK, Md. -- High levels of the enzyme tyrosine threonine kinase (TTK) in many types of cancer cells, including lung cancer, contribute to uncontrolled cell growth. A study published by Frederick National Laboratory Director Ethan Dmitrovsky, M.D. and his laboratory team demonstrated that a promising anti-TTK treatment that acts against many of those types of cancer cells…

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