Posted 3/25/2024
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...
Posted 2/22/2024
There are many paths for women to travel to find success in science. That was a crucial theme conveyed by the four...
Posted 2/7/2024
Frederick National Laboratory researchers identified a vitamin A derivative (retinoid) that when combined with a...
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Frederick National Laboratory Part of SC19 “Best Paper” Team
Posted 1/6/2020A multidisciplinary team including members of the Frederick National Laboratory has been recognized with the “Best Paper” award at SC19, a prestigious international conference for high-performance computing, networking, storage, and analysis. Of the 344 papers submitted to SC19, only 87 were accepted, and just one was named Best Paper.
The research team spent more than two…
Nivolumab Precision Medicine Sub-study Ends with Encouraging Results
Posted 12/30/2019
FREDERICK, Md. -- The cancer drug nivolumab may be effective against more types of tumors than previously thought, according to results from a sub-study of the National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH), the world’s largest precision medicine trial.
Nivolumab (marketed as Opdivo) is currently approved to treat several cancers, including…
FNL is a Partner in Project that Aims to Standardize Measurement of Genetic Blood Tests to Track Cancer
Posted 12/19/2019FREDERICK, Md. – Frederick National Laboratory for Cancer Research is a key partner in a collaboration that aims to standardize the assessment of genetic tests that use blood samples to track cancer in hospitals and laboratories across the United States.
The Foundation for the National Institutes of Health (FNIH) started the project earlier this year as part of its FNIH…
Ebola Study a Source of Hope and Humanity During Violence, Danger, and Disease
Posted 12/16/2019FREDERICK, Md. -- “Sure, it’s easier than doing research in more isolated places, say Antarctica, or outer space—but that does not make it easy for those on the ground. Sometimes densely populated areas pose problems of their own. Not everyone agrees on the need, the presence of so many ‘outsiders,’ or on the approach taken. People were attacked. Research sites were burned…
![Families go to the Ebola Treatment Center to visit a family member who is held in quarantine. [Credit: World Bank/Vincent Tremeau, republished here under CC BY-NC-ND 2.0]](/sites/default/files/styles/thumbnail_feed_list/public/newsimages/1576615372_Ebola%20Trial01.jpg?itok=3jaW2BX7)
Research Team Finds TTK Inhibitor Kills Lung Cancer Cells and Tumors in Mice
Ethan DmitrovskyPosted 12/12/2019
FREDERICK, Md. -- High levels of the enzyme tyrosine threonine kinase (TTK) in many types of cancer cells, including lung cancer, contribute to uncontrolled cell growth. A study published by Frederick National Laboratory Director Ethan Dmitrovsky, M.D. and his laboratory team demonstrated that a promising anti-TTK treatment that acts against many of those types of cancer…
FNL’s Hyun Jung Takes First Place at Medical Imaging Grand Challenge
Posted 12/10/2019
FREDERICK, Md. – Frederick National Laboratory for Cancer Research’s medical imaging expertise received the highest rating at a recent grand challenge for pathology that featured nearly 1,000 competitors from around the world.
Hyun Jung, Ph.D., a bioinformatics analyst, won first place in both parts of the Pathology AI Platform Challenge (PAIP 2019). The event, held in…
Natural products library to boost discovery of earthly compounds
Posted 12/8/2019
FREDERICK, Md. -- Tree bark, microbes, and mold are not simply the stuff you rake in the back yard and track in on the bottom of your shoes. They just might be a treatment for a rare disease.
Products found in nature gave rise to some of our most familiar and relied-upon therapies including some antibiotics and decongestants and aspirin. There may be another treatment…
Ethan Dmitrovsky: X Factor
Posted 11/20/2019"While medicine, like physics, uses probability to help solve its problems, only medicine includes the human element as a factor in its calculations."
Ethan Dmitrovsky, M.D., laboratory director of the Frederick National Laboratory for Cancer Research and president of Leidos Biomedical Research, recently published a story in Pulse: Voices From the Heart of…
New Method for HPV Detection Measures Up to Leading-Edge Techniques
Posted 11/14/2019FREDERICK, Md. -- Scientists at the Frederick National Laboratory for Cancer Research, the National Cancer Institute, and other collaborating institutions have demonstrated that their recently developed technique for detecting human papillomavirus (HPV) in patient samples performs comparably to existing gold-standard methods.
The group validated the technique, an assay…
A Cellular Messenger Protein Calmodulin Can Keep KRAS Away from Membranes Where it Begins its Cascade to Form Cancer
Posted 10/24/2019FREDERICK, Md. -- A study defining how an oncogenic protein gets removed from its active spot may offer new ways to target unwanted cell growth, a hallmark of cancer.
KRAS is a membrane-binding protein that functions as a molecular switch to regulate cellular activity, and is the most frequently mutated oncogene in human cancer. Normal KRAS controls cell growth. When KRAS…
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