HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.…

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly…

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Though rare, HIV leads to blood cancers

Laboratory Animal Sciences ProgramPosted 10/13/2021
HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.

Scientists have long known that HIV contributes to several cancers by weakening the immune system’s ability to fend off cancer-causing infections like Kaposi sarcoma–associated herpesvirus and Epstein-Barr virus. However, this latest study, published…

Meet the Clinical and Translational Serology Task Force

SeroNewsPosted 10/7/2021


The Clinical and Translational Serology Task Force (CTTF) is one of the U.S. National Cancer Institute’s initiatives to respond to the SARS-CoV-2 pandemic.

This is the first installment of its quarterly newsletter. The running publication will include updates about ongoing efforts, information about research, opportunities for communication and…

Study to harmonize serological assay data Is underway

SeroNewsPosted 10/7/2021
The National Cancer Institute–Frederick National Laboratory Clinical and Translational Serology Operations Team is coordinating the Collaborative Assay Harmonization Study. The effort seeks to improve scientists’ ability to compare data between SARS-CoV-2 studies and vaccines.

Participating investigators are comparing the performance of approximately 30 SARS-CoV…

Serological Standard Distributed to Over 80 Groups

SeroNewsPosted 10/7/2021
Since its deployment in December 2020, the U.S. SARS-CoV-2 Serology Standard has been adopted by laboratories near and far.

As of September 15, 2021, there had been 84 requests for the standard from the pharmaceutical industry, U.S. government researchers, the National Cancer Institute's Serological Sciences Network (SeroNet), academic institutions, and…

Assay Evaluation Program Passes 100-Test Milestone

SeroNewsPosted 10/7/2021
Nearly 18 months into its existence, the SARS-CoV-2 serology assay evaluation program is still going strong.

The program’s goal is to identify accurate assays while recognizing those with unacceptable performance. Frederick National Laboratory’s Serology Laboratory has tested more than 100 assays since the program began in April 2020.

The…

Third dose of vaccine authorized for immunocompromised and seniors, studies continue

SeroNewsPosted 10/7/2021


The Food and Drug Administration granted an Emergency Use Authorization in August for immunocompromised individuals and in September for people aged 65 years and older to receive a third dose of an mRNA SARS-CoV-2 vaccine.

Studies are ongoing, but data collected so far indicate that a third, additional dose for these populations would be…

Coronavirus spike protein deteriorates during storage, but it can be restored

National Cryo-EM FacilityPosted 10/6/2021
The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly deteriorates while in storage, which can affect research results and vaccine production, a new study suggests. But the effect can be reversed.

The SARS-CoV-2 spike protein, which is used in laboratories around the world, is unstable under conventional storage…

Like a natural: Scientists seek compounds to target and study rare skin cancer

Basic Science ProgramPosted 9/22/2021
A team of scientists has gone fishing, but they’re interested in more than the bounty of the seas: They’ve also cast out nets on land. And they’ve never left the laboratory.



Their “nets” are high-powered chemical and biological analyses. The team, a group of cancer biologists, dermatologists, biochemists, natural product chemists, and…

Manufacturing and quality assurance expertise by Frederick National Laboratory supports NCI’s pioneering cancer immunotherapy program

Posted 9/15/2021
A grim statistic is driving Steven Rosenberg’s mission to find new cancer treatments—and his partnership with Frederick National Laboratory (FNL) to do so.

“Every year in the United States, about 600,000 people die of cancer, 90% of whom die of the solid epithelial cancers,” said Rosenberg, the M.D., Ph.D., chief of the National Cancer Institute’s (NCI) Surgery…

Technical Service Program provides researchers worldwide with access to unique services

Partnership Development Office, AIDS and Cancer Virus Program, Nanotechnology Characterization Laboratory, Laboratory Animal Sciences ProgramPosted 9/9/2021
The Frederick National Laboratory for Cancer Research (FNL) not only tackles some of the world’s greatest biomedical challenges but also serves as a shared national resource to enable high-quality research beyond its walls. One way FNL does this is through the Technical Services Program.

The Technical Services Program gives investigators worldwide access to…

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