Posted 3/25/2024
Scientists and clinicians whose discoveries have shaped the understanding of HIV disease will provide updates on the...
Posted 2/22/2024
There are many paths for women to travel to find success in science. That was a crucial theme conveyed by the four...
Posted 2/7/2024
Frederick National Laboratory researchers identified a vitamin A derivative (retinoid) that when combined with a...
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Nanotechnology enables potential novel imaging agent for early pancreatic cancer detection
Nanotechnology Characterization Laboratory, Laboratory Animal Sciences ProgramPosted 2/10/2022Frederick National Laboratory (FNL) scientists, led by Stephan Stern, Ph.D., and their colleagues have created a novel imaging agent that, with further development, might detect deadly pancreatic cancer at its earliest, most-treatable stages and thereby improve the prognosis for patients.
Pancreatic cancer has a high mortality rate because it is usually diagnosed late,…
Machine learning-backed model reveals new insights about RAS biology not possible with traditional experiments
Posted 1/26/2022A key to understanding KRAS-driven cancers and the role of mutant RAS proteins and to discover new therapeutic possibilities is to better understand how RAS behaves on the cell membrane.
Investigating RAS in the context of membranes is somewhat challenging using conventional computational or experimental techniques. In a partnership with researchers from three Department…
PET imaging might improve prostate cancer diagnosis and treatment
Clinical Research DirectoratePosted 1/24/2022A pilot study suggests a near real-time method of imaging prostate cancer to aid in organ-sparing treatments, and an innovative as well as accurate way to see whether the cancer has spread.
These dual findings stem from research reported in Molecular Imaging and Biology on a relatively new radiotracer used in dynamic positron emission tomography (PET) to detect levels…
Public-private network ensures accuracy of COVID-19 antibody tests available in US market
Vaccine, Immunity, and Cancer DirectoratePosted 1/20/2022 Frederick National Laboratory for Cancer Research (FNL) plays a central role in a public-private network that has kept scores of substandard COVID-19 blood antibody tests out of circulation and helped ensure that marketed tests give accurate results.
This critical pandemic response is detailed in a scientific study published January 12 in the journal Microbiology…
Growing cancer cells in 3D -- not just 2D -- might improve preclinical drug development
Antibody Characterization Laboratory, Cancer Research Technology ProgramPosted 1/18/2022One way to improve the success rate for new cancer drugs might be to test them in a three dimensional (3D) environment that mimics real life better than the two-dimensional (2D) set-up of a flat culture dish, according to a new study that examined thousands of lung cancer proteins grown under both conditions.
About 95 percent of experimental drugs for lung cancer fail…
Scientists develop new concept for hard-to-treat cancers like mesothelioma
Laboratory Animal Sciences ProgramPosted 1/13/2022Think of a tumor and you might envision a disorganized mass. But tumors can also form a thin sheet over a surface. These can be hard to treat, especially when the surface has wrinkles and crevices. But there may be a new approach.
Solid tumors can be successfully removed with surgery and residual cells destroyed. But cancers like the asbestos-related lung malignancy…
Partnership with FCC aims to support the next generation of STEM in Frederick
Partnership Development OfficePosted 1/11/2022
The Frederick National Laboratory for Cancer Research (FNL) signed a new memorandum of understanding (MOU) with Frederick Community College (FCC) to establish a closer partnership to support the future science, technology, engineering and mathematics (STEM) workforce in Frederick.
“As a scientific organization, we are eager to connect with and inspire the next…
Passion for research and a drive to improve public health motivate Ligia Pinto to embrace challenges of COVID response
Vaccine, Immunity, and Cancer DirectoratePosted 1/6/2022The coronavirus pandemic was heating up and so was the urgent need for blood tests to confirm infections. It was spring 2020, and a host of companies were developing and submitting newly minted tests to the Food and Drug Administration (FDA) for potential Emergency Use Authorization (EUA) approval.
The FDA had to know if the tests were accurate. So the agency contacted…
New partnership with Morehouse School of Medicine on health equity
Partnership Development OfficePosted 12/21/2021The Frederick National Laboratory for Cancer Research (FNL) and Morehouse School of Medicine (MSM) have announced a new strategic partnership to support the mutual exchange of training and research expertise, with a focus on research to improve cancer patient care through precision medicine.
“Morehouse School of Medicine’s mission is to train the next generation of…
Nanotechnology Characterization Laboratory leverages growing industry interest in the technology
Nanotechnology Characterization Laboratory, Cancer Research Technology ProgramPosted 12/16/2021The Nanotechnology Characterization Laboratory is working with industry partners to bolster the use of nanotechnology in drug development and delivery as the interest in the promising technology expands.
“Pharma has initially been hesitant to get into nano because it’s too much risk versus reward,” said Jeffrey D. Clogston, Ph.D., the Physicochemical Characterization…
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