HIV plays a direct role in causing blood cell cancers in rare instances, says a new study of HIV and tumor DNA.…

The spike protein critical for coronavirus research -- and for some COVID-19 vaccines -- slowly…

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Studies show HLA-B gene match with recipient and donor may lead to more successful bone marrow transplant

Posted 7/1/2020
For patients with blood cancer such as leukemia, a bone marrow transplant can extend life or even potentially cure the disease. The ideal bone marrow donor is a close relative, such as a brother or sister. If none is available, doctors look for an unrelated donor whose stem cells best match those of the recipient.


Mary Carrington, Ph.D., director of…

Argonne-FNL collaboration aims to find a SARS-CoV-2 inhibitor

Posted 7/1/2020
A unique library of small-molecule fragments designed and developed by the National Cancer Institute’s RAS Initiative at the Frederick National Laboratory is now furthering the search for a COVID-19 treatment.


Scientist Marcin Dyba holds a tray of compound fragments from the RAS Initiative's tethering library before loading it into the mass…

New technical service supports tuberculosis research

Posted 6/30/2020
The Frederick National Laboratory for Cancer Research has initiated a new technical service offering, to support tuberculosis vaccine research efforts in nonhuman primate (NHP) model studies.


Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB.
Credit: National Institute of Allergy and Infectious Diseases,…

Frederick National Laboratory scientists optimize SARS-CoV-2 protein production to meet growing need for serology testing

Protein Expression LaboratoryPosted 6/24/2020
Scientists at the Frederick National Laboratory for Cancer Research (FNL) successfully increased the yield production of a challenging protein used in antibody tests for SARS-CoV-2, the virus behind COVID-19, publishing their findings earlier this month in Protein Expression and Purification.


3D print of a spike protein on the surface of SARS-CoV-2—also…

Scientific partnership including Frederick National Laboratory develops highly specific test to detect antibodies to COVID-19

Posted 6/16/2020
Scientists at the Frederick National Laboratory for Cancer Research and investigators across the National Institutes of Health (NIH) have developed a highly specific serology test to determine whether a person has antibodies to SARS-CoV-2, a vital tool to understanding the spread of infection from the virus that causes COVID-19.

The collaboration started in…

Study shows HPV35 infection more prevalent in African American women than other groups

Posted 6/14/2020
A type of the human papillomavirus (HPV) that is relatively uncommon among all women is more prevalent among women of African ancestry in the United States according to a National Cancer Institute study published in the International Journal of Cancer and co-authored by scientists at the Frederick National Laboratory for Cancer Research.

HPV is a common…

Analyzing tumors of cancer patients with robust response to treatment may offer clues on how others can benefit and improve tailored treatment

Posted 6/7/2020
Patients who have a better-than-average response to cancer treatment can help further research that might benefit all cancer patients. Analysis of their tumor tissues can provide clues about the genetic keys that make their tumor more responsive to treatment.


Fig 1. Tumor tissue from a patient with Uterine Corpus Endometrial Carcinoma (UCEC) was fixed…

Malian Prime Minister visits CMRPD-supported University Clinical Research Center pivoting to COVID-19 research

Posted 6/4/2020
As word of the SARS-CoV-2 outbreak spread around the world, countries began looking inward to prepare. In Mali, Prime Minister Dr. Boubou Cisse visited University Clinical Research Center (UCRC) laboratories at the University of Sciences, Techniques, and Technologies of Bamako (USTTB) in March to see how its facilities could help.

UCRC provides facilities and…

New England Journal of Medicine paper shows remdesivir speeds recovery for Hospitalized COVID-19 patients

Posted 6/3/2020
The antiviral treatment remdesivir accelerated recovery time among hospitalized participants with advanced COVID-19 compared to participants who received placebo containing inactive ingredients, according to results of a clinical trial published May 22 in the New England Journal of Medicine.

The median time to recovery was 11 days for participants who received…

Collaboration with the London School of Hygiene & Tropical Medicine investigates a single-dose HPV vaccine in Tanzania

Posted 6/1/2020
Is a single dose of a human papillomavirus (HPV) vaccine sufficient to induce an immune response capable of preventing HPV infection and cervical cancer? That is an area of focus of the Frederick National Laboratory’s HPV Serology Laboratory, this time with a new collaboration with the London School of Hygiene & Tropical Medicine School to investigate immune responses…

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